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Bioinformatics and Statistical Genetics

  • Date: 06/10/14
  • Coordinator: Howard Brown
  • Team: Jessica Smith, Tom Fisher, Sarah Branson, Ted Marks
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Introduction

Khartoum Winter School of Bioinformatics and Statistical Genetics is conducted since 2003.It was established by department of molecular biology – IEND. We conducted up to date 13 courses The facilitators and participants discuss approaches, means and domains of integrating disciplines for the study of target diseases and model organisms

Two branches are taught

  1. Bioinformatics

  2. Statistical Genetics

Bioinformatics

The courses introduce participants to the technical aspects of bioinformatics software and the development of bioinformatics software/approaches is included.

Bioinformatics Course Structure:

The course comprise a combination of lecture and hands-on tutorial-like sessions. The following topics are taught :

  1. What is bioinformatics

  2. Bioinformatics standards, programming, and open source developments

  3. Internet/www in bioinformatics

  4. Biological databases and data models

  5. Sequence alignment pairwise, multiple aligment, searching BLAST, using clustalW and Bioedit programe

  6. Primer design

  7. Restriction mapping

  8. Phylogenetic analysis

  9. Structural Bioinformatics

  10. Current topics in bioinformatics and future directions

Statistical genetics

This course is mainly focused on strategies for genetic mapping of human disease genes. The course is for researchers with little or no experience in using statistical genetic analysis programs. The goal of the course is to teach the participants both theory and application of methods for linkage disequilibrium and association studies analysis

Statistical genetics Course Structure:

  1. Aspects of Data collection

  2. Creation of pedigree files

  3. Introduction to Biostatistics

  4. Calculation of Alleles and Genotype frequencies

  5. Association analysis using TDT

  6. Linkage disequilibrium analysis

  7. Haploview program

  8. Structure

  9. Arlequin